食品伙伴網(wǎng)導讀：來(lái)自加拿大蒙特利爾大學(xué)和來(lái)自喀麥隆雅溫得大學(xué)的研究者們發(fā)現：腰果籽的提取物可以促進(jìn)葡萄糖的吸收，這種物質(zhì)可能具有抗糖尿病的功能。在利用大鼠小鼠肝細胞的體外實(shí)驗中，研究者試用過(guò)腰果植株的其他部分---葉子、樹(shù)皮、果實(shí)等---但只有加入了高劑量的腰果籽提取物（CSE）后才促進(jìn)了葡萄糖的吸收。腰果樹(shù)的相關(guān)產(chǎn)品歷來(lái)被認為具有抗炎性能，被用作糖尿病患者中的高血糖患者來(lái)防治胰島素耐受性。在分子營(yíng)養學(xué)與食品調查雜志新出版的研究報道中，研究者針對這種提取物在細胞中對胰島素的響應做了相關(guān)實(shí)驗，研究者稱(chēng)，他們這只是初步的反應，有必要做進(jìn)一步的實(shí)驗來(lái)研究反應機制。
原文報道：
Lab tests have indicated that cashew seed extract could help boost glucose uptake, earmarking it as a compound with potential anti-diabetic properties.
The in vitro tests, conducted using mouse and rat liver cells, found that the stimulatory effect only occurred when high doses of cashew seed extract (CSE) were used. Other parts of the cashew plant – including leaves, barks and apples – were also tested, but were not found to have an effect on glucose uptake.
“Of all the extracts tested, only CSE showed significant stimulatory effect on glucose uptake. Extracts of other plant parts had no such effect, indicating that CSE likely contains active compounds, which can have potential antidiabetic properties,” wrote the researchers from the University of Montreal, Canada, and the Université de Yaoundé, Cameroun.
Insulin response
Cashew tree products have traditionally been thought to have anti-inflammatory properties, to help counter high blood sugar and to prevent insulin resistance among diabetics. The new study, published in the journal Molecular Nutrition & Food Research, set out to examine the impact of these extracts on cells that respond to insulin.
Researchers prepared solutions of cashew seed extract to concentrations of 25, 50 and 100μg/mL. They also prepared a solution of 50μM anacardic acid (AA), which is the active component in cashew seed extract.
These solutions were administered to mouse and rat cells, and incubated for 18 hours, with or without insulin, after which the researchers measured glucose uptake.
Both cashew seed extract and anacardic acid were found to stimulate glucose uptake. In the case of CSE, the effect was only noted at the higher concentration of 100μg/mL.
“Glucose uptake was significantly elevated in cells incubated with high concentration of CSE (100 mg/mL) plus insulin as compared with either CSE or insulin alone and similar results were obtained with AA plus insulin. No such synergistic effect was noticed at lower concentration of CSE,” wrote the researchers.
Potential nutraceutical
They noted that their findings were preliminary, and that further studies were necessary to determine the exact mechanism of action and whether CSE could have a potential anti-diabetic impact on other insulin-responsive tissues or on pancreatic beta cells.
However, they concluded that the current study “validates the traditional use of cashew tree products in diabetes,” and that their results “suggest that CSE may be a potential anti-diabetic nutraceutical.”
原文報道：
Cashew seed extract shows anti-diabetes potential
By Lorraine Heller, 26-Jul-2010Lab tests have indicated that cashew seed extract could help boost glucose uptake, earmarking it as a compound with potential anti-diabetic properties.
The in vitro tests, conducted using mouse and rat liver cells, found that the stimulatory effect only occurred when high doses of cashew seed extract (CSE) were used. Other parts of the cashew plant – including leaves, barks and apples – were also tested, but were not found to have an effect on glucose uptake.
“Of all the extracts tested, only CSE showed significant stimulatory effect on glucose uptake. Extracts of other plant parts had no such effect, indicating that CSE likely contains active compounds, which can have potential antidiabetic properties,” wrote the researchers from the University of Montreal, Canada, and the Université de Yaoundé, Cameroun.
Insulin response
Cashew tree products have traditionally been thought to have anti-inflammatory properties, to help counter high blood sugar and to prevent insulin resistance among diabetics. The new study, published in the journal Molecular Nutrition & Food Research, set out to examine the impact of these extracts on cells that respond to insulin.
Researchers prepared solutions of cashew seed extract to concentrations of 25, 50 and 100μg/mL. They also prepared a solution of 50μM anacardic acid (AA), which is the active component in cashew seed extract.
These solutions were administered to mouse and rat cells, and incubated for 18 hours, with or without insulin, after which the researchers measured glucose uptake.
Both cashew seed extract and anacardic acid were found to stimulate glucose uptake. In the case of CSE, the effect was only noted at the higher concentration of 100μg/mL.
“Glucose uptake was significantly elevated in cells incubated with high concentration of CSE (100 mg/mL) plus insulin as compared with either CSE or insulin alone and similar results were obtained with AA plus insulin. No such synergistic effect was noticed at lower concentration of CSE,” wrote the researchers.
Potential nutraceutical
They noted that their findings were preliminary, and that further studies were necessary to determine the exact mechanism of action and whether CSE could have a potential anti-diabetic impact on other insulin-responsive tissues or on pancreatic beta cells.
However, they concluded that the current study “validates the traditional use of cashew tree products in diabetes,” and that their results “suggest that CSE may be a potential anti-diabetic nutraceutical.”
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