食品伙伴網(wǎng)訊  2020年3月5日，歐盟食品安全局發(fā)布關(guān)于來自一種轉(zhuǎn)基因熒光假單胞菌（Pseudomonas fluorescens）的α-淀粉酶（alpha‐amylase）安全性的評(píng)估結(jié)果。

 

　　據(jù)了解，這種食品酶是由BASF Enzymes LLC1公司用轉(zhuǎn)基因枯草芽孢桿菌菌株BD15754生產(chǎn)的。這種食品酶旨在用于蒸餾酒精生產(chǎn)和用于生產(chǎn)葡萄糖漿的淀粉加工，不含生產(chǎn)生物體的活細(xì)胞和重組DNA。經(jīng)過評(píng)估，專家小組得出結(jié)論，由于這種食品酶存在促進(jìn)耐藥性發(fā)展的風(fēng)險(xiǎn)，被認(rèn)為是不安全的。

 

　　部分原文報(bào)道如下：

 

　　The food enzyme α‐amylase （4‐a‐d‐glucan glucanohydrolase; EC 3.2.1.1） is produced with the genetically modified Pseudomonas fluorescens strain BD15754 by BASF Enzymes LLC1. The food enzyme is free from viable cells of the production organism and recombinant DNA. The α‐amylase is intended to be used in distilled alcohol production and starch processing for the production of glucose syrups. Residual amounts of total organic solids （TOS） are removed by distillation and by the purification steps applied during the production of glucose syrups, consequently, dietary exposure was not calculated. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no observed adverse effect level （NOAEL） at the highest dose of 887 mg TOS/kg body weight （bw） per day. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood of such reactions to occur is considered to be low. However, the food enzyme contains residual amounts of a highly important antimicrobial for human medicine, with the consequent risk of promoting the development of resistance. Therefore, the Panel concludes that the food enzyme α‐amylase, produced with the genetically modified P. fluorescens strain BD15754 cannot be considered safe.

 

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