食品伙伴網(wǎng)訊  2020年5月20日，歐盟食品安全局發(fā)布關(guān)于一種磷脂酶A1（phospholipase A1）安全性的評估結(jié)果。

 

　　據(jù)了解，這種食品酶是由Novozymes A/S公司用轉(zhuǎn)基因黑曲霉（Aspergillus niger）菌株NZYM ‐FP生產(chǎn)的。這種食品酶旨在用于油脂脫膠。經(jīng)過評估，專家小組得出結(jié)論，這種食品酶在預(yù)期使用條件下不會引起安全問題。部分原文報道如下：

 

　　The food enzyme phospholipase A1 （phosphatidycholine 1‐acylhydrolase EC 3.1.1.32） is produced with the genetically modified Aspergillus niger strain NZYM ‐FP by Novozymes A/S. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA . The phospholipase A1 food enzyme is intended to be used for degumming of fats and oils. Since residual amounts of Total Organic Solids （TOS ） are removed by the purification steps applied during degumming, dietary exposure estimation was not considered necessary. Genotoxicity tests did not raise safety concerns. The repeated dose 90‐day oral toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. The Panel identified a no‐observed‐adverse‐effect level （NOAEL ） of 1,356 mg TOS /kg body weight （bw） per day, the highest dose tested. Similarity of the amino acid sequence to those of known allergens was searched and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions upon dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided and the removal of TOS during the degumming of fats and oils, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.

 

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